|How Bacillus subtilis Makes a Spore Part 1:
This lecture segment is suitable for an undergraduate cell biology or microbiology class. Losick provides an excellent introduction to the process of sporulation in B. subtilis, including a discussion of the transcription factors that drive gene expression, and the signaling pathways that regulate transcription factor activation.
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Part 2: In this lecture, the formation of biofilms by B. subtilis is described. Details of the gene network regulating this process are given. Suitable for an advanced undergrad or graduate class in microbiology or gene regulation. Teaching tools are not available for this segment of the talk. See Richard Losick's Seminar >>
Stochasticity and Cell Fate Part 3:
Losick provides a number of examples of stochastically determined cell fate decisions, in both unicellular and mutlicellular organisms.