Research the literature on your own (or suggested assignment)

Wolpert, L. Positional information and the spatial pattern of cellular differentiation. J Theor Biol 25, 1-47 (1969)

What is the French flag model? How does this relate to Bicoid?

Crick, F. Diffusion in embryogenesis. Nature 225, 420-422 (1970).

Do you know of any gene that behaves like the hypothetical substance in Crick’s paper?

Monod, J., Changeux, J. P. & Jacob, F. Allosteric proteins and cellular control systems. J Mol Biol 6, 306-329 (1963)

How does this work relate to the interpretation of the Bicoid gradient by target genes?

Chalfie, M., Tu, Y., Euskirchen, G., Ward, W. W. & Prasher, D. C. Green fluorescent protein as a marker for gene expression. Science 263, 802-805 (1994).

What did Chalfie do for the first time? How did this change the way scientists look at proteins of interest?

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