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Facilitator Questions
Why do you think the Plasmodium replicative cycle is so much longer than the Toxoplasma cell cycle (~48 hr vs ~8 hr)? Parasitologists like to understand the way in which parasites regulate host cell gene expression in the infected cell (and there are some fascinating examples of this). Why might this rationale NOT apply when thinking about Plasmodium falciparum? Why do you think apicomplexan parasites have a polarized cellular architecture? Knowing what you now know about the cell biology of apicomplexa, which organelle would make the best target to develop drugs against, and why? |


