An Introduction to Cell Cycle Regulation
Part 1: Cells reproduce by a series of events known as the cell cycle. Studies in yeast and frog eggs have identified cell-division cycle (cdc) mutants that have allowed cell cycle regulation to be analysed. Two main groups of proteins, the cyclin-dependent kinases (Cdks) and the anaphase-promoting complex or cyclosome (APC or APC/C), are key players in cell cycle control. This is an excellent lecture for undergraduate or graduate students studying the cell cycle
Cyclin-Dependent Kinases and the Cell Cycle
Part 2: In this lecture, Morgan describes work from his lab that addresses how Cdks drive sequential cell-cycle events. He explains how analog-sensitive kinase mutants, together with quantitative mass spectrometry, can be used to identify specific substrates of Cdk. Experiments showed that cyclin specificity determines Cdk substrates and contributes to the ordering of cell-cycle events. This lecture is suitable for graduate students.
The Metaphase to Anaphase Transition
Part 3: This lecture focuses on the control of the metaphase to anaphase transition by the anaphase promoting complex (APC). Experiments indicate that a positive feedback loop downstream of APC promotes the synchronous separation of chromosomes in anaphase. This lecture is suitable for graduate students. No Teaching Tools available for Part 3 of David Morgan’s lecture.